Nicotine Derivatives Patent

It is concluded that of the 05 compounds tested for antimicrobial activity, compound 4a did not show any antibacterial activity. The compounds 4b (400 μg), 4p (200 μg), 4t (500 μg) exhibited inhibitory activity against gram positive bacteria, whereas compound 4h did not exhibit any activity against gram positive bacteria. Similarly compounds 4b (500 μg), 4h (500 μg), 4p (100 μg) exhibited inhibitory activity against gram negative bacteria, whereas compound 4t did not exhibit any activity against gram negative bacteria. Out of these 05 compounds 4p has shown promising antibacterial activity.

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